Methods

59 overweight, mildly obese, otherwise healthy females with a history of daily dietary fat consumption greater than or equal to 30% of total calories participated in a randomized double-blind placebo-controlled trial. Subjects received either three capsules of a rapidlysoluble chitosan (LipoSan Ultra™) or matched placebo twice daily for eight weeks. Supplementation was divided into two doses, 1.5 g each, and was taken just prior to the two largest meals of the day. No food restrictions or modifications were assigned, and subjects were instructed to continue their regular caloric intake. Dietary calorie and fat intake was monitored during the study by three-day diet diaries completed at baseline and at weeks four and eight. Anthropometric measurements and functional gastrointestinal and elimination symptoms were measured at baseline and week eight.